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Glossary HAART Highly Active Antiretroviral Therapy ART Antiretroviral Therapy Tat Trans activator of Transcription PLWH People living with HIV CVD Cardiovascular Disease PAH Pulmonary Arterial Hypertension PH Pulmonary Hypertension PH-LHD Pulmonary Hypertension with left heart disease cART Combination Antiretroviral Therapy HAND HIV-associated neurocognitive disorder LTR Long Terminal Repeat TAR Transactivation Response Region NF-κB Nuclear Factor kappa B TRAF6 Tumor Necrosis Factor Receptor-Associated Receptor 6 SIV Simian Immunodeficiency Virus CNS Central Nervous System ECs Endothelial Cells VCAM-1 Vascular Cell Adhesion Molecule 1 ECLAM-1 Endothelial Leucocyte Adhesion Molecule-1 ICAM-1 Intracellular Adhesion Molecule-1 TLR4 Toll-like Receptor 4 PKC Protein Kinase C MAP Mitogen-Activated Protein Kinase TNFα Tumor Necrosis Factor-alpha IL-10 Interleukin-10 IL-1β Interleukin-1 beta IL-6 Interleukin-6 MCP-1 Monocyte Chemoattractant Protein-1 BBB Blood Brain Barrier HBMECs Human Brain Microvascular Endothelial Cells CCL-2 C-C Motif Chemokine Ligand 2 TJs Tight Junctions Zo-1 Zonula Occludens-1 VEGFR1 Vascular Endothelial VEGFR2 Vascular Endothelial Growth Factor Receptor 2 CREB Cyclic AMP Response Element-Binding Protein PPARγ Peroxisome Proliferator-Activated Receptor Bcl2 B-cell lymphoma 2 Bax Bcl-2-associated X protein MMP-9 Matrix Metalloproteinase-9 RAGE Receptor for Advanced Glycation End Products LRP1 Low-Density Lipoprotein Receptor-Related Protein 1 TRPV2 Transient Receptor Potential Vanilloid 2 ROS Reactive Oxygen Species SOD2 Superoxide Dismutase 2 NO Nitric Oxide NOXA1 NADPH oxidase 1 KDR Kinase Insert Domain Receptor HLMVEC Human Lung Microvascular Endothelial Cells PAK1 p21-activated kinase 1 Tip60 Tat interacting Protein 60 kDa RGD Arginine-Glycine-Aspartic MnSOD Manganese Superoxide Dismutase JAM-2 Junctional Adhesion Molecule 2 WHO World Health Organization TRIF TIR-domain-containing adapter-inducing interferon-beta PASP Pulmonary Artery Systolic Pressure NSG-BLT NOD-scid IL2Rγnull Bone Marrow-Liver-Thymus Humanized Mice JNK c-Jun N-terminal kinase PDGFR-β Platelet-Derived Growth Factor Receptor beta PLWH People Living with HIV